Keywords:Clopidogrel Bisulphate, Gastroretentive Drug Delivery System (GRDDS), Floating Drug Delivery System (FDDS), Gastric Residence Time, Controlled Release

ABSTRACT

Modern oral drug delivery techniques known as gastroretentive drug delivery systems (GRDDS) are intended to lengthen the time spent in the stomach by a medication, which increases its bioavailability and therapeutic effectiveness when it is absorbed in the the upper gastrointestinal tract or showing localized gastric activity. These systems are particularly helpful for medications with low intestinal solubility or a limited absorption window. Floating systems are one of the ways that GRDDS works. remain afloat on gastric fluids, bioadhesive systems that stick to the stomach lining, and swelling systems that extend to systems with multiple particles that provide dosage flexibility and regulated release, as well as mechanisms to prevent early gastric emptying. Clopidogrel, a common antiplatelet drug, has low oral bioavailability due to its restricted solubility at alkaline pH and limited absorption window. By extending gastric residence time and increasing drug absorption, gastric retentive drug delivery systems (GRDDS), notably floating drug delivery systems (FDDS), have become promising techniques. The goal of this work was to create and test a gastroretentive floating tablet of Clopidogrel Bisulphate that would increase bioavailability by means of a continuous drug release and prolonged gastric retention. The tablets were created using compression methods with polymers (hydroxypropyl methylcellulose) and effervescent compounds. Pre- and post-compression testing of the compositions included assessments of hardness, friability, weight variation, floating lag time (FLT), total floating time (TFT).