Keywords:Antioxidant, Xanthophylls, anthocyanins, lignans, stilbenes, Gamma Oryzenol

ABSTRACT

The goal of the current investigation is to ascertain the assessment profile of the miconazole nitrate cream and nanoemulsion formulations. Using the principles of low-energy emulsification and miconazole nitrate cream, nanoemulsion were prepared at concentrations of 1%, 1.5%, and 2%. The preparation was then physically evaluated using tests such as organoleptic analysis, pH measurement, viscosity analysis, emulsion type, centrifugation, cycling, particle size measurement using a particle size analyzer, and homogeneity analysis of cream preparations. It is evident from the organoleptic test that the miconazole nitrate nanoemulsion formulations that are made are transparent, have a faint yellow tint, and have a white cream. While the cream preparations had an average pH of 5.91–6.57, the nanoemulsion preparations had an average pH of 6.11–6.37. The average viscosity values of nanoemulsion preparations were 1701 cps, 1917 cps, and 1981 cps, respectively. The cream preparation stayed white and did not undergo phase separation in the cycling test, while the nanoemulsion preparation remained weakly yellow and unscented. In the centrifugation test, the cream and the nanoemulsion preparation were centrifuged for five hours at a rate of 3800. Following the centrifugation tests, neither the cream preparation nor the nanoemulsion preparation displayed any phase separation, which may have been caused by the preparation's high viscosity. Methylene blue is dripped onto the formula in the type nanoemulsi test. Following observation, the blue methylene is uniformly distributed throughout the formula, suggesting that all four formulas contain an oil-in-water (o/w) emulsion type. The prepared nanoemulsion has particle sizes ranging from 101.31 nm to 302.18 nm.