Keywords:Proton pump, Proteolysis, Gastroprotective, Anthraquinones, Ulceration.

ABSTRACT

Gastric acid, gastric juice, and stomach acid are all terms for the digestive fluid produced by the lining of the stomach. Gastric acid, which has a pH of 1–3, is crucial for protein breakdown because it triggers the release of digestive enzymes that collaborate to break down the lengthy chains of amino acids that make up proteins. Feedback systems manage stomach acid production when it is needed, such as after a meal. The current investigation demonstrated that D. hamiltonii leaf extract has strong antiulcer action, validating its widespread usage by the local community in the treatment of stomach ulcer. In comparison, ranitidine 20 mg/kg provided 86.02% protection under the same conditions, while pretreatment of rats with the aqueous extract at the amounts used (50, 100, and 200 mg/kg) resulted in 52.11%, 61.17%, and 74.04% protection against gastric mucosal damage, respectively. In a water immersion stress-induced ulcer model, aqueous leaf extract of D. hamiltoni at 50, 100, and 200 mg/kg showed 71.41%, 75.04%, and 80.53% protection, respectively, while Ranitidine showed 82.12% protection. Displays the outcomes achieved with the extract in this experimental scenario. At dosages of 50, 100, and 200 mg/kg, D. hamiltoni offered significant protection, with ulcer indexes of 52.71%, 60.34%, and 74.83%, respectively. Ranitidine, the usual treatment, provided 92.31% protection.