Keywords:Hydroxy Propyl Cellulose, Hydroxy Propyl Methyl Cellulose, Loose Bulk Density, migrating mylo electric cycle, Sustaied release tablet.

ABSTRACT

A pharmaceutical formulation in the form of tablets that combines temporal and spatial control for optimum therapeutic outcomes is the subject of the current invention. A third generation cephalosporin antibiotic is cefixime. With a bioavailability of 40–50%, cefixime is absorbed slowly and incompletely from the GIT. Direct compression method was used to make the gas-powered tablets of Cefixime with varying concentrations of hydrophilic polymers in order to extend the duration of gastric retention. Pre-compressional parameters were applied to the powder mixture. Post-compressional analysis of the prepared tablets was performed for characteristics including hardness, friability, weight variation, thickness, diameter, drug content, lag time, buoyancy time, and in-vitro dissolution studies. DSC and FTIR investigations were conducted to assess the compatibility of medications with excipients. The hardness test results for all the formulations revealed good mechanical strength, while the friability was less than 1%, suggesting that the tablets had a high mechanical resistance. The study revealed that the drug release rate decreases as the sodium bicarbonate concentration rises from 50 to 80 mg/tab, but the lag time decreases as the sodium bicarbonate concentration and duration of floating increase. DSC and FT-IR studies revealed no incompatibility between the drug and the excipients utilized. The stability investigation carried out in accordance with ICH guidelines showed that the formulations were stable. According to this study, the formulation remained in the stomach for a longer period of time (spatial control), allowing for regulated release of the medication. Therefore, by enhancing the drug's bioavailability, the therapeutic impact is improved.